The role of candidate gene polymorphisms for endothelial dysfunction and metabolic disorders in the development of cardiovascular diseases under the influence of production factors

Endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. Genetic predisposition, metabolic disorders and other effects, including occupational hazards, can lead to formation endothelial dysfunction. The study aims assess polymorphisms candidate genes development diseases persons with pathology. Scientists have found that carriage certain alleles G894T nitric oxide synthase gene, Lys198Asp G8002A endothelin-1, Met235Thr Thr174Met angiotensinogen -2548G/A, 19G/A G2453A leptin, 668A/G Gln223Arg leptin receptor, determining structure proteins-markers syndrome, as well some production factors (exposure vibration, exposure vinyl chloride, mercury, fluorine aluminum compounds), all these are close connection